Collagen XXII, a novel human collagen and uses thereof

US7125666B2 · kind B2 · utility

Assignee

• The General Hospital Corporation · US

Inventors

• Robert Burgeson · Marblehead, US
• Manuel Koch · Cambridge, US
• Douglas R. Keene · Portland, US
• William Brunken · Hingham, US
• Leena Bruckner-Tuderman · Munster, DE

Key dates

• Filing date: Jul 24, 2002
• Grant date: Oct 24, 2006
• Expiry date: May 20, 2023

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07K14/78
• WIPO field: Biotechnology
• WIPO sector: Chemistry

Abstract

The invention provides isolated nucleic acids molecules, designated collagen XXII nucleic acid molecules, which encode a novel collagen. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing collagen XXII nucleic acid molecules, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which a collagen XXII gene has been introduced or disrupted. The invention still further provides isolated collagen XXII proteins, fusion proteins, antigenic peptides and anti-collagen XXII antibodies. Diagnostic methods utilizing compositions of the invention are also provided.