Methods and materials for characterizing and modulating interaction between heregulin and HER3

US7125680B2 · kind B2 · utility

Assignee

• The Regents of the University of California · US

Inventors

• Elizabeth Singer · Duarte, US
• Ralf Landgraf · San Fernando, US
• Dennis Slamon · Los Angeles, US
• David S. Eisenberg · Los Angeles, US

Key dates

• Filing date: Jul 29, 2002
• Grant date: Oct 24, 2006
• Expiry date: Oct 24, 2023

Classification

• Technology area (CPC G): Physics
• CPC primary: G01N2333/9121
• WIPO field: Biotechnology
• WIPO sector: Chemistry

Abstract

The disclosure provided herein identifies and characterizes the domain in HER3 receptor that interacts with heregulin ligand. Typical embodiments of the invention disclosed herein include methods for identifying compounds which specifically bind the heregulin binding domain in HER3.