Elastin-based compositions
US7125837B1 · kind B1 · utility
Assignee
Inventors
Key dates
| Filing date | Feb 28, 2000 |
| Grant date | Oct 24, 2006 |
| Priority date | — |
| Expiry date | Feb 28, 2020 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61P9/10
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention provides screening methods that use organisms or cells that lack function in one or both elastin genes. These methods are useful in identifying drugs for the prevention and treatment of obstructive vascular diseases, such as atherosclerosis, vascular restenosis and transplant arteriopathy. Further, the invention provides pharmaceutical compositions containing elastin-based compositions that are particularly potent regulators of proliferation, differentiation, and migration of smooth muscle cells in vitro and in vivo. These pharmaceutical compositions and related methods are useful in the prevention and treatment of disorders characterized by diminished capacity to regulate smooth muscle cell function.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.