β-sheet mimetics and use thereof as inhibitors of biologically active peptides or proteins

US7125872B2 · kind B2 · utility

Assignee

• Myriad Genetics, Inc. · US

Inventors

• Michael Kahn · Los Angeles, US
• Cyprian O. Ogbu · Bellevue, US
• Masakatsu Eguchi · Bellevue, US
• Hwa-Ok Kim · Lexington, US
• Patrick Douglas Boatman, Jr. · San Diego, US

Key dates

• Filing date: Dec 22, 2003
• Grant date: Oct 24, 2006
• Expiry date: Feb 4, 2024

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07K5/1024
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

There are disclosed β-sheet mimetics and methods relating to the same for imparting or stabilizing the β-sheet structure of a peptide, protein or molecule. In one aspect, β-sheet mimetics are disclosed having utility as protease inhibitors in general and, more specifically, as serine protease inhibitors such as thrombin, elastase and Factor X inhibitors. In one embodiment, the β-sheet mimetic is a thrombin inhibitor.