Substituted amidoalkyl uracils and their use as inhibitors of the poly(adp-ribose) synthetase (PARS)

US7125995B2 · kind B2 · utility

Assignee

• BAYER HEALTHCARE LLC · DE

Inventors

• Barbara Albrecht · Wuppertal, DE
• Michael Gerisch · Wuppertal, DE
• Gabriele Handke-Erguden · Uerdingen, DE
• Axel Jensen · Velbert, DE
• Thomas Krahn · Hagen, DE
• Werner Nickl · Waldkirch, DE
• Felix Oehme · Wuppertal, DE
• Karl-Heinz Schlemmer · Wuppertal, DE
• Henning Steinhagen · Pocking, DE

Key dates

• Filing date: Nov 2, 2001
• Grant date: Oct 24, 2006
• Expiry date: Jun 8, 2022

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D495/04
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

This application relates to compounds of formula (I) belowin which the several variable groups are as defined in the specification and claims, to methods of preparing these materials, to pharmaceutical compositions containing these materials, and to methods of using these materials to treat ischaemia or reperfusion damage.