Method of synthesizing camptothecin-relating compounds
US7126000B2 · kind B2 · utility
55Cited by
1References
27Claims
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Key dates
| Filing date | Feb 21, 2002 |
| Grant date | Oct 24, 2006 |
| Priority date | — |
| Expiry date | Jul 17, 2022 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY02P20/55
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
The present invention is to prepare efficiently 2′-amino-5′-hydroxypropiophenone corresponding to the AB-ring part of camptothecin (CPT) skeleton and a tricyclic ketone corresponding to the CDE-ring part in order to provide efficiently CPT by the total synthesis, which is a starting material for irinotecan hydrochloride and various kinds of camptothecin derivatives, and to provide stably CPT and its derivatives.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.