Process for preparing 4-pentafluorosulfanylbenzoylguanidines

US7126026B2 · kind B2 · utility

Assignee

• Sanofi-Aventis Deutschland GMBH · DE

Inventors

• Gerrit Schubert · Kelkheim, DE
• Heinz-Werner Kleemann · Bischofsheim, DE

Key dates

• Filing date: Nov 15, 2004
• Grant date: Oct 24, 2006
• Expiry date: Nov 15, 2024

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07C381/00
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

A process for preparing 4-pentafluorosulfanylbenzoylguanidines of formula Iwherein R1 to R4 have the meanings indicated in the specification. The compounds of formula I are NHE1 inhibitors and can be employed, for example, for the treatment of cardiovascular disorders.