Material containing metal ion ligand complex producing nitric oxide in contact with blood

US7128904B2 · kind B2 · utility

Assignee

• THE REGENTS OF THE UNIVERSITY OF MICHIGAN · US

Inventors

• Melissa M. Batchelor · Ann Arbor, US
• Bong Kyun Oh · Ann Arbor, US
• Mark E. Meyerhoff · Ann Arbor, US

Key dates

• Filing date: Jan 16, 2002
• Grant date: Oct 31, 2006
• Expiry date: Oct 3, 2023

Classification

• Technology area (CPC B): Performing Operations; Transporting
• CPC primary: B01J31/1805
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Biocompatible materials that have the ability to release nitric oxide (NO) in situ at the surface-blood interface when in contact with blood. The materials which may be polymers (e.g., polyurethane, poly(vinyl chloride), silicone rubbers), metals, such as stainless steel, carbon, and the like are provided with biocatalysts or biomimetic catalysts on their surface that have nitrite, nitrate, and/or nitrosothiol-reducing capability. Illustratively, the catalysts are adsorbed or immobilized at the surface of the material. The catalysts can act on endogenous nitrite, nitrate, or nitrosothiols within the blood creating a local increase in the NO levels at the surface of the material. An illustrative enzymatic biocatalyst is mammalian xanthine oxidase. In another illustrative embodiment, a biomimetic catalyst is a copper (Cu(II)-ligand complex, e.g. dibenzo[e,k]-2,3,8,9-tetraphenyl-1,4,7,10-tetraaza-cyclododeca-1,3,7,9-tetraene. In some cases, lipophilic salts of nitrite/nitrate (e.g., tridodecylmethylammonium nitrite (TDMA+NO2−/NO3−)) or certain salts of nitrosothiols can be doped within a polymer material, or an underlying polymeric film, to create a reservoir of nitrite or nitrosothio…