Export systems for recombinant proteins

US7129060B1 · kind B1 · utility

Assignee

• Max-Planck-Gesellschaft zur Föderung der Wissenschaften e.V. · US

Inventors

• Jochen MAURER · Bingen, DE
• Joachim Jose · Mülheim an der Ruhr, DE
• Thomas F. Meyer · Tübingen, DE

Key dates

• Filing date: Mar 15, 1996
• Grant date: Oct 31, 2006
• Expiry date: Mar 15, 2016

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07K2319/035
• WIPO field: Biotechnology
• WIPO sector: Chemistry

Abstract

The present invention relates to vectors, host-vector combinations and processes for preparing stable fusion proteins consisting of a carrier protein and a passenger protein, where expression of the fusion proteins leads to exposure of the passenger domains on the surface of bacterial cells, especially Escherichia coli cells. If required, the passenger domains can be released into the medium by proteases, for example by selected host factors such as, for example, OmpT.