Crystal of fibroblast growth factor receptor 1 in complex with fibroblast growth factor
US7129072B1 · kind B1 · utility
41Cited by
0References
1Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Aug 30, 2000 |
| Grant date | Oct 31, 2006 |
| Priority date | — |
| Expiry date | Aug 30, 2020 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07K2299/00
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
The determination and use of three dimensional structures of receptor protein tyrosine kinases and/or their ligands are described. One particular group of such structures includes three dimensional structures of the extracellular domain of RPTKs. The three dimensional structures of RPTKs can faciliate the design and identification of modulators of RPTK function. Other such structures can include of RPTK ligands, such as stem cell factor or a fragment thereof. Modulators of RPTK function can be used to treat diseases that are mediated by inappropriate RPTK activity.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.