Hydrazide building blocks and hydrazide modified biomolecules

US7129229B2 · kind B2 · utility

Assignee

• Nanogen Recognomics GmbH · DE

Inventors

• Stefan Raddatz · Wiesbaden, DE
• Jochen Muller-Ibeler · Diez, DE
• Markus Schweitzer · Frankfurt am Main, DE
• Christoph Brucher · Eschborn, DE
• Norbert Windhab · Hofheim, DE
• John Havens · San Diego, US
• Thomas J. Onofrey · San Marcos, US
• Charles Greef · Louisville, US
• Daguang Wang · White Plains, US

Key dates

• Filing date: Aug 10, 2001
• Grant date: Oct 31, 2006
• Expiry date: Oct 10, 2022

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07F9/2429
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

This invention relates to attachment chemistries for binding macromolecules to a substrate surface or to other conjugation targets. More particularly, this invention relates to attachment chemistries involving branched or linear structures having one or more hydrazide attachment moieties for binding the macromolecules to a substrate surface, or for other conjugation reactions. Novel modifying reagents are provided for the introduction of protected hydrazide attachment moieties or precursor forms of such hydrazides to the macromolecule, either as a single hydrazide or as multiple hydrazides.