Identification of Candida albicans essential fungal specific genes and use thereof in antifungal drug discovery
US7129341B1 · kind B1 · utility
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2Claims
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Key dates
| Filing date | May 5, 2000 |
| Grant date | Oct 31, 2006 |
| Priority date | — |
| Expiry date | May 5, 2020 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12Q1/6895
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
The invention relates to the identification and disruption of essential fungal specific genes isolated in the yeast pathogen Candida albicans namely CaKRE5, CaALR1, and CaCDC24 and to the use thereof in antifungal diagnosis and as essential antifungal targets in a fungal species for antifungal drug discovery. More specifically, the invention relates to the CaKRE5, CaALR1, and CaCDC24 genes, to their use to screen for antifungal compounds and to the drugs identified by such.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.