Transporter compositions and methods for detecting and killing cells in acidic areas of tumors
US7132393B2 · kind B2 · utility
14Cited by
1References
25Claims
0Family size
Assignee
Inventor
Key dates
| Filing date | Feb 28, 2005 |
| Grant date | Nov 7, 2006 |
| Priority date | — |
| Expiry date | Feb 28, 2025 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K38/16
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Improved transporter compositions effective for detecting or killing cells in acidic areas of tumors are described. Each composition includes a transporter peptide which at pH 7.2 and above is poly-anionic and so repels from cells in normal tissues, but at lower pH in hypoxic areas of tumors the transporter peptide converts to a non-ionic lipophilic form which transports across membranes of cells. Each composition also includes a cargo component which can be pulled across cell membranes by the transporter peptide and which is effective for detecting or killing cells into which the transporter composition has entered.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.