Benzothiazepine and benzothiazepine derivatives with ileal bile acid transport (IBAT) inhibotory activity for the treatment hyperlipidaemia

US7132416B2 · kind B2 · utility

Assignee

• ASTRAZENECA AB · SE

Inventors

• Ingemar Starke · Gothenburg, SE
• Mikael Dahlstrom · Timrå, SE
• David Blomberg · Mölndal, SE
• Suzanne Alenfalk · Hultsfred, SE
• Tore Skjaret · Hultsfred, SE
• Malin Lemurell · Mölndal, SE

Key dates

• Filing date: Sep 5, 2002
• Grant date: Nov 7, 2006
• Expiry date: Sep 5, 2022

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D285/36
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present invention relates to compounds of formula (I) wherein Rv, R1, R2, Rx, Ry, M, Rz, v, R3, R4, R5 and R6 are as defined within; pharmaceutically acceptable salts, solvates, solvates of such salts and prodrugs thereof and their use as ileal bile acid transport (IBAT) inhibitors for the treatment of hyperlipidaemia. Processes for their manufacture and pharmaceutical compositions containing them are also described.