Pharmaceutical compounds
US7132419B2 · kind B2 · utility
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11Claims
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Assignee
Inventors
Key dates
| Filing date | Dec 30, 2004 |
| Grant date | Nov 7, 2006 |
| Priority date | — |
| Expiry date | Dec 30, 2024 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D241/46
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
A compound which is a benzo[a]phenazine-11-carboxamide derivative of formula (I)wherein each of R1 to R4, which are the same or different, is selected from hydrogen, halogen, hydroxyl, C1–C6 alkoxy which is unsubstituted or substituted, heteroaryloxy, C1–C6 alkyl which is unsubstituted or substituted, nitro, cyano, azido, amidoxime, CO2R10, CON(R12)2, OCON(R12), SR10, SOR11, SO2R11, SO2N(R12)2, N(R12)2, NR10SO2R11, N(SO2R11)2 NR10(CH2)nCN, NR10COR11, OCOR11 or COR10; These compounds are inhibitors of topoisomerase I and/or topoisomerase II and can be used to treat tumours, including tumours which express MDR.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.