3,4-Di-substituted cyclobutene-1,2-diones as CXC-chemokine receptor ligands

US7132445B2 · kind B2 · utility

Assignees

• SCHERING CORPORATION · US
• Pharmacopeia Drug Discovery, Inc. · US

Inventors

• Arthur G. Taveras · Rockaway, US
• Cynthia Aki · Livingston, US
• Richard Bond · Union, US
• Jianping Chao · Summit, US
• Michael P. Dwyer · Scotch Plains, US
• Johan Ferreira · Bethlehem, US
• Jianhua Chao · Pompton Lakes, US
• Younong Yu · East Brunswick Township, US
• John J. Baldwin · Gwynedd Valley, US
• Bernd Kaiser · Plainsboro, US
• Ge Li · Shanghai, CN
• J. Merritt · Ewing, US
• Purakkattle Biju · Piscataway, US
• Kingsley Nelson · Mebane, US
• Laura Rokosz · Union, US
• James P. Jakway · Bound Brook, US
• Gaifa Lai · Edison, US
• Minglang Wu · Monmouth Junction, US
• Evan Hecker · Arlington, US
• Daniel Lundell · Flemington, US
• Jay Fine · Bloomfield, US

Key dates

• Filing date: Jul 30, 2003
• Grant date: Nov 7, 2006
• Expiry date: May 11, 2024

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07C2602/08
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

There are disclosed compounds of the formulaor a pharmaceutically acceptable salt or solvate thereof which are useful for the treatment of chemokine-mediated diseases such as acute and chronic inflammatory disorders and cancer.