Triaza- and tetraaza-anthracenedione derivatives, their preparation and their use as pharmaceuticals

US7132536B2 · kind B2 · utility

Assignee

• Sanofi-Aventis Deutschland GMBH · DE

Inventors

• Andreas Weichert · Egelsbach, DE
• Hartmut Strobel · Liederbach, DE
• Paulus Wohlfart · Frankfurt am Main, DE
• Marcel Patek · Tucson, US
• Martin Smrcina · Tucson, US
• Aleksandra Weichsel · Tucson, US

Key dates

• Filing date: Apr 21, 2004
• Grant date: Nov 7, 2006
• Expiry date: Apr 21, 2024

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D487/04
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

The present invention relates to triaza- and tetraaza-anthracenedione derivatives of the formula I,wherein A, B and R1 to R5 are as defined herein. The compounds of formula I are valuable pharmacologically active compounds. They are useful in the treatment of various disease states including cardiovascular disorders such as atherosclerosis, thrombosis, coronary artery disease, hypertension and cardiac insufficiency. They upregulate the expression of the enzyme endothelial nitric oxide (NO) synthase and can be applied in conditions in which an increased expression of said enzyme or an increased NO level or the normalization of a decreased NO level is desired. The invention furthermore relates to processes for the preparation of compounds of the formula I, their use, in particular as active ingredients in pharmaceuticals, and pharmaceutical preparations comprising them.