Compositions and techniques for localized therapy
US7135189B2 · kind B2 · utility
36Cited by
8References
22Claims
0Family size
Assignee
Inventor
Key dates
| Filing date | Aug 23, 2001 |
| Grant date | Nov 14, 2006 |
| Priority date | — |
| Expiry date | Oct 11, 2023 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61L2300/622
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
A therapeutic medical article is provided which comprises a medical article, a precursor compound and an activator compound. The medical article is adapted, upon administration to a patient, to release the precursor compound and the activator compound such that the activator compound interacts with the precursor compound and converts the precursor compound into activated form for local delivery. Specific examples of precursor and activator compound pairs include: (a) a nitrosothiol precursor and a nitric oxide donor, (b) plasminogen and plasminogen activator, and (c) fibrinogen and thrombin.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.