Cationic lipid compositions targeting angiogenic endothelial cells
US7135192B2 · kind B2 · utility
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20Claims
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Key dates
| Filing date | Apr 2, 2004 |
| Grant date | Nov 14, 2006 |
| Priority date | — |
| Expiry date | Dec 17, 2024 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12N15/88
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Angiogenic endothelial cells are selectively targeted with lipid/DNA complexes or cationic liposomes containing a substance which affects the targeted cells by inhibiting or promoting their growth. A site of angiogenesis can be precisely located by administering cationic liposomes containing a detectable label. The complexes may comprise nucleotide constructs which are comprised of promoters which are selectively and exclusively activated in the environment of an angiogenic endothelial cell.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.