Viral particles with exogenous internal epitopes
US7135282B1 · kind B1 · utility
1Cited by
10References
10Claims
0Family size
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Key dates
| Filing date | Oct 13, 2000 |
| Grant date | Nov 14, 2006 |
| Priority date | — |
| Expiry date | Oct 29, 2022 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY10S530/826
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention relates to the expression of peptides on viral particles, and more particularly to the expression of peptides on the interior or the viral capsid. Methods are described for modifying viruses so that exogenous epitopes are expressed on the interior of the viral capsid. Viruses that can be modified include (+) stranded RNA viruses, especially plant (+) stranded RNA viruses such as the cowpea mosaic virus. Internal expression is especially useful for the expression of hydrophobic epitopes. The modified viral particles also find use as vaccines and as such are capable of eliciting an immune response.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.