Topoisomerase type II gene polymorphisms and their use in identifying drug resistance and pathogenic strains of microorganisms
US7135283B1 · kind B1 · utility
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Key dates
| Filing date | Nov 17, 1998 |
| Grant date | Nov 14, 2006 |
| Priority date | — |
| Expiry date | Nov 17, 2018 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12Q2600/156
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
Novel polymorphisms of prokaryotic topoisomerase type II Gyr A, Gyr B and parC gene loci are provided. These polymorphisms differentiate very closely related organisms and provide a means to identify pathogenicity and drug resistance. For example, drug resistance such as resistance to methicillin, a drug which is not metabolically tied to topoisomerase function, may be determined by polymorphisms in the Gyrase A locus. Identification of such drug resistance by such unrelated loci is indicative of heretofore unrecognized [sub]species of Staphylococcus aureus.
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