Patent · US Expired

Urea and urethane derivatives as integrin inhibitors

US7135587B2 · kind B2 · utility

0Cited by

1References

18Claims

0Family size

Assignee

Merck Patent GmbH · DE

Inventors

Wolfgang Staehle · Ingelheim am Rhein, DE
Alfred Jonczyk · Darmstadt, DE
Oliver Schadt · Rodenbach, DE
Simon Goodman

Key dates

Filing date	Nov 30, 2001
Grant date	Nov 14, 2006
Priority date	—
Expiry date	Jul 21, 2022

Classification

Technology area (CPC C)Chemistry; Metallurgy
CPC primaryC07D235/30
WIPO fieldPharmaceuticals
WIPO sectorChemistry

Abstract

Novel urea and urethane derivatives of general formula (I) in which R1, R2, R3, R5, R5′, X, Y, B, m, n and o are as defined in Patent Claim 1, and physiologically acceptable salts or solvates thereof are integrin inhibitors and can be employed for combating thromboses, cardiac infarction, coronary heart disease, arteriosclerosis, inflammation, tumors. Osteoporosis, infections and restenosis after angioplasty or in pathological processes maintained or propagated by antiogenesis.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.