Interactions of ATM, ATR or DAN-PK with p53
US7138236B1 · kind B1 · utility
3Cited by
2References
2Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Jul 16, 1998 |
| Grant date | Nov 21, 2006 |
| Priority date | — |
| Expiry date | Jul 16, 2018 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG01N2333/91205
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
The interaction of ATM and related protein kinases such as ATR and DNA-PK with p53 is disclosed, in particular the phosphorylation of Ser15 and Thr18 by these proteins. The activity of the proteins is shown to increase in the presence of DNA. Assays for modulators of phosphorylation by the interaction between the proteins and p53 or other proteins having similar phosphorylation sites are provided. Methods of purifying ATM or ATR employing DNA or NTA are also disclosed.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.