Polypeptides having sialytransferase activity
US7138258B2 · kind B2 · utility
9Cited by
3References
12Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Nov 21, 2002 |
| Grant date | Nov 21, 2006 |
| Priority date | — |
| Expiry date | Nov 21, 2022 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12P19/18
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
This invention provides prokaryotic glycosyltransferases, including a bifunctional sialyltransferase that has both an α2,3- and an α2,8-activity. A β1,4-GalNAc transferase and a β1,3-galactosyltransferase are also provided by the invention, as are other glycosyltransferases and enzymes involved in synthesis of lipooligosaccharide (LOS). The glycosyltransferases can be obtained from, for example, Campylobacter species, including C. jejuni. In additional embodiments, the invention provides nucleic acids that encode the glycosyltransferases, as well as expression vectors and host cells for expressing the glycosyltransferases.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.