Non-imidazole alkylamines as histamine H3-receptor ligands and their therapeutic applications

US7138413B1 · kind B1 · utility

Assignee

• BIOPROJET · FR

Inventors

• Jean-Charles Schwartz · Paris, FR
• Monique Garbarg · Paris, FR
• Jeanne-Marie Lecounte · Paris, FR
• Xavier Ligneau · Brive-la-Gaillarde, FR
• Walter G Schunacx · Berlin, DE
• Hulger Stark · Berlin, DE
• Charon R. Ganellin · Welwyn Garden City, GB
• Fabien Leurquin · London, GB
• Sigurd Elz · Berlin, DE
• Jean-Michel Arrang · Gif-sur-Yvette, FR

Key dates

• Filing date: Jul 29, 1999
• Grant date: Nov 21, 2006
• Expiry date: Jul 29, 2019

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07C2602/10
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Use of a compound of formula (A), wherein: W is a residue which imparts antagonistic and/or agonistic activity at histamine H3-receptors when attached to an imidazole ring in 4(5) position; R1 and R2 may be identical or different and represent each independently a lower alkyl or cycloalkyl, or taken together with the nitrogen atom to which they are attached, a saturated nitrogen-containing ring (i) as defined, a non-aromatic unsaturated nitrogen-containing ring (ii) as defined, a morpholino group, or a N-substituted piperazino group as defined for preparing medicaments acting as antagonists and/or agonists at the H3-receptors of histamine