Anti-androgenic pyrrolidines with tumor-inhibiting action

US7138421B2 · kind B2 · utility

Assignee

• Schring Aktiengesellschaft · DE

Inventors

• Arwed Cleve · Berlin, DE
• Volker Schulze · Berlin, DE
• Dieter Zopf · Marburg, DE
• Jens Hoffmann · Nettetal, DE
• Andreas Reichel · Berlin, DE
• Karsten Parczyk · Berlin, DE

Key dates

• Filing date: May 10, 2004
• Grant date: Nov 21, 2006
• Expiry date: Jun 26, 2024

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D403/06
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

This invention relates to anti-androgenic N-[ω-[3-[4-cyano-3-(trifluoromethyl)-phenyl]-5,5-dimethyl-4-oxo-2-thioxoimidazolidin-1-yl]alkyl]-substituted pyrrolidines of general formula I,with a strongly pronounced antiproliferative profile of action; process for the production of the compounds of general formula I, pharmaceutical preparations and the use for the production of pharmaceutical agents.