Reagents and methods for mycophenolic acid immunoassay
US7138504B2 · kind B2 · utility
2Cited by
13References
15Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Aug 11, 2005 |
| Grant date | Nov 21, 2006 |
| Priority date | — |
| Expiry date | Aug 11, 2025 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07K16/44
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
The invention teaches derivatives of mycophenolic alcohol and methods of preparing immunogens and other conjugates useful in immunoassays for quantitatively measuring concentrations of mycophenolic acid (MPA) and/or active metabolites of MPA in patient specimens. Antibodies produced from the disclosed immunogens capable of binding to MPA with cross-reactivity of no more than 5% with inactive metabolites and commonly co-prescribed drugs. Further, immunoassays for measuring the concentration of MPA using such antibodies are taught.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.