Thiophene amidines, compositions thereof, and methods of treating complement-mediated diseases and conditions

US7138530B2 · kind B2 · utility

Assignee

• 3-Dimensional Pharmaceuticals, Inc. · US

Inventors

• Nalin Subasinghe · Exton, US
• Ehab M. Khalil · Yorktown, US
• Kristi A. Leonard · West Chester, US
• Farah Ali · Exton, US
• Heather Rae Hufnagel · Glenmoore, US
• Jeremy Travins · Southborough, US
• Shelley K. Ballentine · Lansdale, US
• Kenneth T. Wilson · New Garden Township, US
• Maxwell D. Cummings · Strafford, US
• Wenxi Pan · Radnor, US
• Joan Gushue · Harleysville, US
• Sanath K. Meegalla · Boothwyn, US
• Mark Wall · Lansdale, US
• Jinsheng Chen · Exton, US
• Jonathan Rudolph · Doylestown, US
• Hui Huang · Blue Bell, US

Key dates

• Filing date: May 28, 2003
• Grant date: Nov 21, 2006
• Expiry date: Jun 19, 2023

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07F9/655345
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Disclosed is a method for treating the symptoms of an acute or chronic disorder mediated by the classical pathway of the complement cascade, comprising administering to a mammal in need of such treatment a therapeutically effective amount of a compound of Formula (I) or a solvate, hydrate or pharmaceutically acceptable salt thereof; wherein R1, R2, R3, R4 and R7 are defined in the specification, Z is SO or SO2, and Ar is an aromatic or heteroaromatic group as defined herein.