Computational method for designing enzymes for incorporation of non natural amino acids into proteins
US7139665B2 · kind B2 · utility
21Cited by
1References
30Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Feb 27, 2003 |
| Grant date | Nov 21, 2006 |
| Priority date | — |
| Expiry date | May 3, 2024 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG16B15/00
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
The instant invention provides methods, reagents, and computational tools for designing non-natural substrate analogs for enzymes, especially for designing unnatural amino acid analogs for aminoacyl tRNA Synthetases (AARSs), such as the Phe tRNA Synthetase. The instant invention also provides methods to incorporate unnatural amino acid analogs, especially those with interesting functional groups, into protein products to generate proteins of modified or novel functions.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.