Assessment of liver fibrosis scoring with serum marker algorithms

US7141380B2 · kind B2 · utility

Inventors

• Michael Volker
• Michael Becka · Neheim, DE
• Werner Kroll · Solingen, DE
• Andreas M. Knorr · Erkrath, DE
• Mathias Gehrmann · Tönisvorst, DE
• Guido Hennig · Wynau, CH
• Sylvia Unger · Heidelberg, DE
• Elmar Burchardt · Wuppertal, DE
• Michael Arthur · Romsey, GB
• Alastair D. Burt · Rothbury, GB
• Massimo Pinzani · Scandicci, IT
• Detlef Schuppan · Mainz, DE

Key dates

• Filing date: Apr 26, 2001
• Grant date: Nov 28, 2006
• Expiry date: May 13, 2022

Classification

• Technology area (CPC G): Physics
• CPC primary: G01N2800/085
• WIPO field: Measurement
• WIPO sector: Instruments

Abstract

The present invention concerns a method for diagnosing liver fibrosis wherein two or more diagnostic markers are measured and the measurements are correlated by a mathematic algorithm characterized in that the diagnostic markers are selected from the group N-terminal procollagen III propeptide (PIIINP), Collagen IV, Collagen VI, Tenascin, Laminin, Hyaluronan, MMP-2, TIMP-1 and MMP-9/TIMP-1 complex. The algorithm can be used to predict the histological score of a liver biopsy.