Stabilization of pharmaceutical protein formulations with small peptides
US7141544B2 · kind B2 · utility
15Cited by
15References
15Claims
0Family size
Assignees
Inventors
Key dates
| Filing date | Oct 10, 2003 |
| Grant date | Nov 28, 2006 |
| Priority date | — |
| Expiry date | Oct 10, 2023 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K38/1816
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention relates to stable pharmaceutical protein formulations that are stabilized using peptide stabilizers selected from the group consisting of Gly-Gly, Gly-Gly-Gly, Gly-Tyr, Gly-Phe, Gly-His, Gly-Asp, Gly-Ala, Ala-Gly, Ala-Ala, derivatives thereof and mixtures thereof. Furthermore, the present invention relates to stable pharmaceutical formulations comprising erythropoietin and peptide stabilizers selected from dipeptides, tripeptides, tetrapeptides, pentapeptides, and mixtures thereof. In addition to peptide stabilizers, the formulations may contain surfactants.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.