Glucocorticoid receptor ligands for the treatment of metabolic disorders

US7141559B2 · kind B2 · utility

Assignee

• Karo Bio AB · SE

Inventors

• Richard D. Bishop · Third Lake, US
• Russell D. Cink · Grayslake, US
• Bradley D. Gates · Mount Prospect, US
• Lars Hagberg · Huddinge, SE
• Peer B. Jacobsen · Libertyville, US
• Philip R. Kym · Libertyville, US
• Chunqiu Lai · Libertyville, US
• Marvin R. Leanna · Grayslake, US
• James T. Link · Stanford, US
• Steven Richards · Brisbane, US
• Noah Tu · Gurnee, US
• Tom von Geldern · Richmond, US

Key dates

• Filing date: Jun 12, 2003
• Grant date: Nov 28, 2006
• Expiry date: Dec 22, 2023

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07J1/00
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

This invention relates to novel compounds that are liver selective glucocorticoid receptor antagonists, to methods of preparing such compounds, and to methods for using such compounds in the regulation of metabolism, especially lowering serum glucose levels, insulin levels, or lipid levels, and/or decreasing body weight.