Hydrazono-malonitriles

US7141572B2 · kind B2 · utility

Assignee

• Merck Patentgesellschaft · DE

Inventors

• Hans-Michael Eggenweiler · Darmstadt, DE
• Michael Wolf · Darmstadt, DE
• Norbert Beier · Reinheim, DE
• Pierre Schelling · Mühltal, DE
• Thomas Ehring · Remscheid, DE

Key dates

• Filing date: Oct 10, 2002
• Grant date: Nov 28, 2006
• Expiry date: Mar 7, 2023

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D237/04
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Hydrazono-malonitrile derivatives of the formula (I) in which R1, R2, R3, R3′ and R4 have the meanings given in Claim 1 act as phosphodiesterase IV inhibitors and can be employed for the treatment of osteoporosis, tumours, cachexia, atherosclerosis, rheumatoid arthritis, multiple sclerosis, diabetes mellitus, inflammatory processes, allergies, asthma, autoimmune diseases, myocardial diseases and AIDS