Small molecule inhibition of a PDZ-domain interaction
US7141600B2 · kind B2 · utility
4Cited by
5References
18Claims
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Key dates
| Filing date | Apr 15, 2004 |
| Grant date | Nov 28, 2006 |
| Priority date | — |
| Expiry date | Apr 15, 2024 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D209/18
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
Novel compounds that have been found effective in inhibiting PDZ domain interactions, and particularly interactions of PDZ domains in MAGIs with the oncogenic (tumor suppressor) protein PTEN and interactions between the PDZ domain in the Dishevelled (Dvl) protein and other proteins such as the Frizzled (Fz) protein, have the general formulaThe invention also includes combinatorial libraries, arrays and methods for screening and studying proteins using such compounds.Compounds of the invention have produced apoptosis in certain cell lines that overexpress the Dishevelled protein (Dvl); inhibiting Wnt signaling.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.