Methods for producing substituted acrylic acid esters and use of the latter for producing substituted γ-amino acids

US7141695B2 · kind B2 · utility

Assignee

• GRUNENTHAL GMBH · DE

Inventors

• Michael Przewosny · Aachen, DE
• Claudia Pütz · St. Blasien, DE

Key dates

• Filing date: Jul 19, 2004
• Grant date: Nov 28, 2006
• Expiry date: Mar 13, 2025

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07C67/343
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

The invention relates to methods for producing substituted acrylic acid esters and to the use of the latter for producing substituted γ-amino acids, such as gabapentin and pregabalin. The substituted acrylic acid esters are produced by Wadsworth-Emmons olefination with trialkyl phosphonoacetate in the presence of alkali carbonate as the base, in an aqueous solvent.