Prodrugs of thrombin inhibitors

US7144902B1 · kind B1 · utility

Assignee

• Abbott GmbH & Co. KG · DE

Inventors

• Dorit Baucke · Mannheim, DE
• Helmut Mack · Ludwigshafen, DE
• Werner Seitz · Plankstadt, DE
• Wilfried Hornberger · Wiesbaden, DE
• Gisela Backfisch · Dossenheim, DE
• Juergen Delzer · Ludwigshafen, DE

Key dates

• Filing date: Apr 5, 2000
• Grant date: Dec 5, 2006
• Expiry date: Apr 5, 2020

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61K38/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present invention relates to prodrugs of pharmacologically active five-membered heterocyclic amidines from which are produced in vivo compounds which are competitive inhibitors of trypsin-like serine proteases, in particular thrombin and kininogenases such as kallikrein, to the preparation thereof and to the use thereof as medicines. The invention also relates to pharmaceutical compositions which comprise the prodrugs of the active compounds as ingredients, and to the use of the compounds as thrombin inhibitors, anticoagulants and as antiinflammatory agents.