Crystalline forms of carbapenem antibiotics and methods of preparation
US7145002B2 · kind B2 · utility
30Cited by
10References
6Claims
0Family size
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Key dates
| Filing date | Sep 20, 2002 |
| Grant date | Dec 5, 2006 |
| Priority date | — |
| Expiry date | Dec 25, 2022 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61P31/04
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
A process for preparing a crystalline, carbapenem monosodium salt of formula IIa:characterized by the steps a) adding about 10 to 30% of an organic solvent to an aqueous solution of the carbapenem, b) cooling the resulting solution to less than −5° C., c) adjusting the pH using a solution containing an acid in an organic solvent to give the appropriate pH for crystallization, and d) crystallizing the compound by adding methanol, and a C2-5 alcohol at between −5 and −25° C.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.