Structural carotenoid analogs for the inhibition and amelioration of disease

US7145025B2 · kind B2 · utility

Assignee

• Hawaii Biotech Inc. · US

Inventors

• Samuel Lockwood · Lake Linden, US
• Sean O'Malley · Honolulu, US
• David G. Watumull · Honolulu, US
• Laura M. Hix · San Francisco, US
• Henry Jackson · Honolulu, US
• Geoff Nadolski · Kaaawa, US

Key dates

• Filing date: Jul 29, 2003
• Grant date: Dec 5, 2006
• Expiry date: Oct 9, 2023

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07H13/04
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

A method for inhibiting and/or ameliorating the occurrence of diseases associated with reactive oxygen species, reactive nitrogen species, radicals and/or non-radicals in a subject whereby a subject is administered a carotenoid structural analog, either alone or in combination with another carotenoid analog, or co-antioxidant formulation. The analog or analog combination is administered such that the subject's risk of experiencing diseases associated with reactive oxygen species, reactive nitrogen species, radicals and/or non-radicals may be thereby reduced. The analog or analog combination may be administered to a subject for the inhibition and/or amelioration of ischemia-reperfusion injury, liver disease, cancer, cardiac arrhythmia and/or sudden cardiac death, and/or any disease that involves production of reactive oxygen species, reactive nitrogen species, radicals and/or non-radicals. In one embodiment, a water-soluble and/or water-dispersible astaxanthin analog is particularly effective. This invention further includes pharmaceutical compositions comprising structural carotenoid analogs either alone or in combination.