Chimeric bird from embryonic stem cells
US7145057B2 · kind B2 · utility
22Cited by
10References
9Claims
0Family size
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Key dates
| Filing date | Feb 1, 2002 |
| Grant date | Dec 5, 2006 |
| Priority date | — |
| Expiry date | Feb 1, 2022 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12N2840/203
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
Sustained cultures of avian embryonic stem cells are provided. Injection of avian embryonic stem cells into recipient embryos yields chimeras with a significant contribution from the embryonic stem cell phenotype. Transgene encoding exogenous proteins are stably integrated in the embryonic stem cells and are present in the somatic tissue of the resulting chimeras. The transgenes may encode exogenous proteins expressed in endodermal, ectodermal, mesodermal, or extra embryonic tissue. Breeding the resulting chimera yields transgenic birds whose genome is comprised of exogenous DNA.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.