Prosthetic grafts
US7147846B2 · kind B2 · utility
20Cited by
25References
36Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Mar 3, 2004 |
| Grant date | Dec 12, 2006 |
| Priority date | — |
| Expiry date | Mar 2, 2025 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12N2799/04
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
An improved prosthetic graft for the bypass, replacement or repair of vessels and organs that are in contact with blood flow is disclosed. The prosthetic graft includes a porous prosthetic implant and adherent cells adhered to the outer surface of the implant. The adherent cells are transfected with at least one recombinant nucleic acid molecule encoding at least one protein that enhances patency of the graft. The prosthetic graft has a long-term patency and success rate that is superior to other previously described prosthetic grafts designed for such use. Also disclosed are methods of making and using such a graft.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.