Complex of Hepatitis B virus polymerase with p11 and method for controlling movement of the complex in HepG2 cell
US7148013B2 · kind B2 · utility
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Key dates
| Filing date | Aug 7, 2003 |
| Grant date | Dec 12, 2006 |
| Priority date | — |
| Expiry date | Jun 24, 2024 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12N2740/16222
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Disclosed is a complex of the 11 kDa Ca2+ binding protein of 11 and Hepatitis B virus polymerase (HBVPol) which moves to Promyelocytic Leukemia Nuclear Body (PMLNB). Furthermore, the present invention discloses a method for controlling movement of the HBVPol/p11 complex into the nucleus of HepG2 cell with adjusting of intracellular Ca2+ ion concentration by administrating an agent for controlling calcium ion concentration in HepG2 cells.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.