Process for production of steroid crystals, steroid crystals obtained thereby and pharmaceutical preparations containing them

US7148212B2 · kind B2 · utility

Assignee

• SCHERING CORPORATION · US

Inventors

• Detlef Grawe · Kleinromstedt, DE
• Hagen Gerecke · Jena, DE
• Peter Hoesel · Jena, DE
• Annette Eichardt · Jena, DE
• Sabine Gliesing · Jena, DE
• Uwe Mueller · Jena, DE

Key dates

• Filing date: Apr 17, 2003
• Grant date: Dec 12, 2006
• Expiry date: Aug 25, 2024

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61P43/00
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

The process for making steroid crystals having a predetermined average particle size of from 1 μm to 25 μm and a maximum particle size that does not exceed a predetermined maximum value of 100 μm, includes subjecting a supersaturated solution containing a steroid to a wet milling by wet milling apparatus while crystallizing, in order to obtain a primary particle suspension. Crystals obtained according to this process and pharmaceutical preparations containing them are also described.