Cycloalkyl derivatives having bioisosteric carboxylic acid groups, processes for their preparation and their use as pharmaceuticals

US7148246B2 · kind B2 · utility

Assignee

• Sanofi-Aventis Deutschland GMBH · DE

Inventors

• Dirk Gretzke · Frankfurt am Main, DE
• Heiner Glombik · Hofheim, DE
• Eugen Falk · Frankfurt am Main, DE
• Jochen Goerlitzer · Frankfurt am Main, DE
• Stefanie Keil · Frankfurt am Main, DE
• Hans-Ludwig Schaefer · Frankfurt am Main, DE
• Christian Stapper · Mainz, DE
• Wolfgang Wendler · Bad Camberg, DE

Key dates

• Filing date: Feb 27, 2004
• Grant date: Dec 12, 2006
• Expiry date: Feb 27, 2024

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D413/12
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

Cycloalkyl derivatives having bioisosteric carboxylic acid groups, processes for their preparation and their use as pharmaceuticals What is described are compounds of the formula I,in which the radicals are as defined, and their physiologically acceptable salts and processes for their preparations. The compounds are suitable for the treatment and/or prevention of disorders of fatty acid metabolism and glucose utilization disorders as well as of disorders in which insulin resistence is involved.