Process for preparing macrocyclic compounds

US7148347B2 · kind B2 · utility

Assignee

• Boehringer Ingelheim International GmbH · DE

Inventors

• Joerg Brandenburg · Ingelheim am Rhein, DE
• Kai Donsbach · Hargesheim, DE
• Hans-Dieter Ecker · Gau-Algesheim, DE
• Rogelio P. Frutos · Sandy Hook, US
• Fabrice Gallou · Danbury, US
• Dieter Gutheil · Bretzenheim, DE
• Nizar Haddad · Danbury, US
• Robert Hagenkoetter · Idstein, DE
• Dirk Kemmer · Windesheim, DE
• Jutta Kroeber · Bingen, DE
• Thomas Nicola · Ingelheim am Rhein, DE
• Juergen Schnaubelt · Biberach, DE
• Michael Schul · Plaidt, DE
• Robert D. Simpson · Wilmington, US
• Xudong Wei · West Greenwich, US
• Eric Winter · Pittsburgh, US
• Yibo Xu · Ridgefield, US
• Nathan K. Yee · Seattle, US

Key dates

• Filing date: Apr 6, 2004
• Grant date: Dec 12, 2006
• Expiry date: Sep 14, 2024

Classification

• Technology area (CPC B): Performing Operations; Transporting
• CPC primary: B01J2531/821
• WIPO field: Biotechnology
• WIPO sector: Chemistry

Abstract

Disclosed is a process for preparing a macrocyclic compound of the formula (I):which is carried out using an intermediate of the formula (II):wherein W, R1 through R4, D, A and R12 are as defined herein. The compounds of formula (I) are potent active agents for the treatment of hepatitis C virus (HCV) infection.