Truncated aggrecanase molecules
US7150983B2 · kind B2 · utility
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6References
2Claims
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Key dates
| Filing date | Feb 5, 2003 |
| Grant date | Dec 19, 2006 |
| Priority date | — |
| Expiry date | Feb 5, 2023 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61P43/00
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Truncated aggrecanase proteins and nucleotides sequences encoding them as well as processes for producing them are disclosed. Additionally, aggrecanases with amino acid mutations that lead to increased stability and expression levels in comparison with wild-type or native aggrecanases are also disclosed. Aggrecanases of the invention are especially useful for development of compositions for treatment of diseases such as osteoarthritis. Methods for developing inhibitors of the aggrecanase enzymes and antibodies to the enzymes for treatment of conditions characterized by the degradation of aggrecan are also disclosed.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.