Pyrazole compounds as transforming growth factor (TGF) inhibitors
US7151110B2 · kind B2 · utility
7Cited by
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3Claims
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Key dates
| Filing date | Sep 23, 2005 |
| Grant date | Dec 19, 2006 |
| Priority date | — |
| Expiry date | Sep 23, 2025 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D405/14
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Novel pyrazole compounds, including derivatives thereof, to intermediates for their preparation, to pharmaceutical compositions containing them and to their medicinal use are described. The compounds of the present invention are potent inhibitors of transforming growth factor (“TGF”)-β signaling pathway. They are useful in the treatment of various TGF-related disease states including, for example, cancer, and fibrotic diseases.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.