Antimicrobial polymeric surfaces

US7151139B2 · kind B2 · utility

Assignees

• Massachusetts Institute of Technology · US
• Trustees of Tufts College · US

Inventors

• Joerg Tiller · Herdecke, DE
• Chun-Jen Liao · Taipei, TW
• Kim Lewis · Newton, US
• Alexander M. Klibanov · Boston, US

Key dates

• Filing date: Apr 16, 2002
• Grant date: Dec 19, 2006
• Expiry date: Apr 16, 2022

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61L27/34
• WIPO field: Medical technology
• WIPO sector: Instruments

Abstract

Bactericidal compositions are disclosed that comprise a polymeric compound immobilized on a material. Medical devices are also disclosed which comprise such a bactericidal composition. Methods are disclosed for covalently derivatizing the surfaces of common materials with an antibacterial polycation, e.g., poly(vinyl-N-pyridinium bromide); the first step of the methods involves coating the surface with a nanolayer of silica. Various commercial synthetic polymers derivatized in this manner are bactericidal, i.e., they kill on contact up to 99% of deposited Gram-positive and Gram-negative bacteria, whether deposited through air or water.