Process for the preparation of 7-alkyl-10-hydroxy-20(S)-camptothecin
US7151179B2 · kind B2 · utility
3Cited by
1References
16Claims
0Family size
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Key dates
| Filing date | May 12, 2004 |
| Grant date | Dec 19, 2006 |
| Priority date | — |
| Expiry date | Apr 4, 2025 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61P35/00
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
The key intermediate in any synthesis of Irinotecan is 7-ethyl-10-hydroxy-20(S)-camptothecin. A process for the efficient synthesis of this intermediate is demonstrated proceeding through readily available 20(S)-camptothecin. Various other tecan compounds may be made by use of corresponding 7-alkyl-10-hydroxy-20(S)-camptothecin intermediates.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.