Image analysis of the golgi complex
US7151847B2 · kind B2 · utility
Assignee
Inventors
Key dates
| Filing date | Feb 20, 2001 |
| Grant date | Dec 19, 2006 |
| Priority date | — |
| Expiry date | Oct 22, 2021 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG01N2015/1472
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
Methods, code and apparatus analyze cell images to automatically identify and characterize the Golgi complex in individual cells. This is accomplished by first locating the cells in the image and defining boundaries of those cells that subsume some or all of the Golgi complex of those cells. The Golgi complex in the images typically have intensity values corresponding to the concentration of a Golgi component in the cell (e.g. a polysaccharide associated with the Golgi complex). The method/system then analyzes the Golgi components of the image (typically on a pixel-by-pixel basis) to mathematically characterize the Golgi complex of individual cells. This mathematical characterization represents phenotypic information about the cells' Golgi complex and can be used to classify cells. From this information, mechanism of action and other important biological information can be deduced.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.