Patent · US Expired

8-(biaryl)quinoline PDE4 inhibitors

US7153968B2 · kind B2 · utility

5Cited by
3References
23Claims
0Family size

Assignee

Inventors

Key dates

Filing dateJun 23, 2003
Grant dateDec 26, 2006
Priority date
Expiry dateJul 13, 2023

Classification

  • Technology area (CPC C)Chemistry; Metallurgy
  • CPC primaryC07F9/60
  • WIPO fieldOrganic fine chemistry
  • WIPO sectorChemistry

Abstract

8-(biaryl) quinolines wherein the bi-aryl group at the 8-position is in a meta relationship to the quinoline group, are PDE4 inhibitors useful in the treatment of asthma, chronic bronchitis, chronic obstructive pulmonary disease, eosinophilic granuloma, psoriasis and other benign or malignant proliferative skin diseases, endotoxic shock, laminitis in horses, colic in horses, septic shock, ulcerative colitis, Crohn's disease, reperfusion injury of the myocardium and brain, inflammatory arthritis, chronic glomerulonephritis, atopic dermatitis, urticaria, adult respiratory distress syndrome, chronic obstructive pulmonary disease in animals, diabetes insipidus, allergic rhinitis, allergic conjunctivitis, vernal conjunctivitis, arterial restenosis, ortherosclerosis, atherosclerosis, neurogenic inflammation, pain, cough, rheumatoid arthritis, ankylosing spondylitis, transplant rejection, graft versus host disease, hypersecretion of gastric acid, bacterial, fungal induced sepsis, viral induced sepsis, fungal induced septic shock, viral induced septic shock, inflammation-mediated chronic tissue degeneration, cytokine-mediated chronic tissue degeneration, osteoarthritis, cancer, cachexia, m…

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.